Benefits of Immune System Balance
MyLife Mangosteen Essence is the result of numerous years of research and dedication. Xanthones derived from the mangosteen fruit has been combined with a proprietary blend of essential minerals and other key phytonutrients which can enhance the human immune system. The key is balance. Xanthones have been shown to reduce Interleukin 1 and increase Interleukin 2. Interleukin 1 is released when there is an immediate injury to the body, as evidenced by inflammation, swelling and a febrile response. This is appropriate, but an unchecked continuation of this process could adversely affect the host and even cause death. Therefore at some point this process must be turned off. The increase in Interleukin 2 thus facilitates the repair and regeneration of healthy tissue at the cellular level.
MyLife Mangosteen Essence xanthones has found the key to help the immune system to fine tune this very delicate balance of Interleukin 1 & 2 in our body. This is important as we age when the immune system starts to fail and to be challenged by environmental toxins. The human body in all of its remarkable ability to repair and heal itself may succumb to adverse events. The xanthones of MyLife Mangosteen Essence, synergized by other active ingredients in the essence, have been shown to boost these immune factors which may help to prevent numerous debilitation disease processes.
As we live longer, we also wish to have an enhanced quality of life. MyLife Mangosteen Essence can help boost the immune system to achieve wellness and longevity as well as diminish certain debilitating diseases.
Contributed by Lewanzer Lassiter M.D., F.A.C.O.G.
RESEARCH
Antioxidation and antimalarial activities of xanthones from mangosteen
Assoc. Prof. Dr. Wilawan Mahabusarakam
Department of Chemistry, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
Dr. Metta Ongsakul
Department of Microbiology, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
นงพร โตวัฒนะ
Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hatyai, Songkhla, Thailand
ประพนธ์ วิไลรัตน์
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
In cardiovascular disease, it has been generally accepted that oxidative modification of LDL plays a critical role in atherosclerosis. Therefore, antioxidants able to interfere with lipid peroxidation may be beneficial in reducing atherogenic process. GM-1, a major xanthone in the fruit hulls of Garcinia mangostana, was shown for the first time to be a free radical scavenger protecting the LDL from oxidative damage in vitro in 1995. Some years later, a series of GM-1 derivatives were prepared and then tested for their activities on LDL oxidation. Some of them exhibited more profound effects than GM-1 itself. Therefore, some structural modifications of GM-1 are capable of enhancing its antioxidant activity.
GM-1 and its derivatives have also been shown to be antiplasmodial, antioxidant, and inhibiting eukaryote protein kinases and cyclic nucleotide-binding phosphatase.
Anti-bacterial activies of xanthones from mangosteen
Assoc. Prof. Dr. Souwalak Phongpaichit
Natural Products Research Center, Department of Microbiology, Mangosteen Research and Development Center,
Asian Phytoceuticals Public Co., Ltd.
Wilawan Mahabusarakam
Natural Products Research Center, Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
Metta Ongsakul
Department of Microbiology, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
โสภา คำมี
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
World health problems caused by drug-resistant bacteria are increasing. Methicillin-resistant Staphylococcus aureus (MRSA) has become a major pathogen causing hospital and community acquired infections. MRSA infections are more difficult to treat due to the antibiotic-resistance of the bacteria. GM-1 and GM-3, major xanthones from mangosteen (Garcinia mangostana) exhibited antibacterial activity against MRSA comparable to a standard drug vancomycin. Mangosteen xanthone cream can effectively treat skin infection as compared with commercial antibiotics. In addition, these xanthones inhibited the growth of Enterococcus sp.
Anti-inflammation of xanthones from mangosteen
Assoc. Prof. Dr. Ampai Panthong
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
and Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
Xanthones in mangosteen posses anti-inflammatory activity and the most active one is GM-1. The detailed study of GM-1 for its anti-inflammation and analgesia showed that GM-1 exhibited stronger anti-inflammatory activity three times over that of aspirin as seen in carrageenin-induced rat paw edema, rat pleurisy and on the primary lesion of adjuvant-induced arthritis models. In addition GM-1 also showed inhibitory activity in chronic inflammation as found in cotton pellet-induced granuloma formation and on the secondary lesion of adjuvant-induced arthritis in rats. Furthermore GM-1 elicited analgesic effect when tested in acetylcholine-induced writhing response in mice. The investigation of analgesic effect of the products from mangosteen (as food supplement) in volunteers with joint pain and gastric ulcer will also be presented.
Molecular investigation on anti-cartilage degradation by xanthones from mangosteen
Assoc. Prof. Dr. Prachya Kongtawelert
Thailand Excellence Center for Tissue Engineering, Department of Biochemistry,
Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., and
Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
Asst. Prof. Dr. Siriwan Ongchai
Thailand Excellence Center for Tissue Engineering, Department of Biochemistry,
Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., and
Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
Osteoarthritis (OA) is the most common form of arthritis. It results from an imbalance between predominantly chondrocyte-controlled anabolic and catabolic processes, and is characterized by progressive degradation of the components of the extracellular matrix (ECM) of the articular cartilage, associated with secondary inflammatory factors.
The effect of xanthones from mangosteen on the cartilage degradation in vitro and human chondrocyte culture was investigated. GM-1 was found to be the most active, comparable to or even better than the drugs presently prescribed for osteoarthritis. The detail of this findings together with the molecular mechanism and mode of action will be presented.